Urticaria / Angioedema

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What is Urticaria / Angioedema?

Urticaria, commonly known as hives, is a skin reaction characterized by raised, red, itchy welts that can appear anywhere on the body. Angioedema is a related condition that causes deeper swelling beneath the skin, often affecting areas such as the lips, eyelids, hands, feet, or throat.

Both conditions result from an immune system response, often triggered by allergens, medications, infections, or other environmental factors. While urticaria primarily affects the superficial skin, angioedema involves deeper layers and can sometimes be life-threatening if it obstructs the airway.

Are Urticaria / Angioedema common?

Yes, urticaria is a common condition that affects up to 20% of people at some point in their lives. Angioedema is less common but can occur alongside urticaria or independently. Episodes can be acute (lasting less than six weeks) or chronic (lasting more than six weeks).

Can Urticaria / Angioedema be cured?

Acute episodes often resolve on their own or with treatment, while chronic urticaria or angioedema may require ongoing management. Identifying and avoiding triggers, using medications to control symptoms, and monitoring for severe reactions are essential for effective management.

Causes

What causes Urticaria / Angioedema?

Causes vary and can include:

  • Allergic reactions – to foods, medications, insect stings, or latex
  • Physical triggers – pressure, cold, heat, sunlight, or exercise
  • Infections – viral, bacterial, or fungal infections
  • Medications – antibiotics, NSAIDs, ACE inhibitors, or contrast dyes
  • Chronic autoimmune conditions – where the immune system attacks its own tissues
  • Idiopathic – in many chronic cases, the exact cause may remain unknown

What are the risk factors?

You may be more likely to develop urticaria or angioedema if you:

  • Have a personal or family history of allergies
  • Have other atopic conditions such as asthma, eczema, or allergic rhinitis
  • Take medications known to trigger hives or swelling
  • Are exposed to certain foods, insect bites, or environmental allergens

With Insurance

Without Insurance

*Price Effective 12/1/2025
$169
Initial Visit
$109
Follow Up

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Symptoms

What are the symptoms of Urticaria / Angioedema?

Symptoms can range from mild to severe and include:

Urticaria (hives):

  • Raised, red, itchy welts on the skin
  • Welts may vary in size and shape
  • Can appear anywhere on the body and migrate over hours
  • Often accompanied by a burning or stinging sensation

Angioedema:

  • Deep swelling of lips, eyelids, tongue, throat, hands, or feet
  • Pain or pressure in swollen areas
  • Difficulty breathing or swallowing if the throat is involved (medical emergency)
  • May occur with or without visible hives

Severe angioedema, especially involving the airway, requires immediate emergency attention.If you experience swelling of your tongue, lips, or throat, difficulty breathing, or feel faint, use epinephrine if prescribed and call 911 immediately.

Diagnosis

How are Urticaria / Angioedema diagnosed?

Diagnosis involves:

  • Medical history – detailing onset, triggers, and duration of symptoms
  • Physical examination – observing the appearance and pattern of hives or swelling
  • Blood tests – to check for autoimmune conditions or underlying infections
  • Allergy testing – skin prick or blood tests to identify triggers
  • Challenge tests – sometimes used for suspected food or medication triggers
  • Imaging – in rare cases, to rule out underlying conditions causing angioedema

Proper diagnosis is essential to determine the cause, prevent triggers, and plan treatment.

Treatment

How are Urticaria / Angioedema treated?

Treatment focuses on symptom relief, preventing triggers, and managing severe reactions:

Lifestyle and preventive measures:

  • Avoid known allergens or triggers
  • Keep a symptom diary to identify patterns
  • Wear loose clothing to minimize irritation

Medications:

  • Antihistamines – first-line treatment to reduce itching and hives
  • Corticosteroids – for severe or persistent reactions
  • Epinephrine (adrenaline) – for life-threatening angioedema or anaphylaxis
  • Immunomodulatory drugs – for chronic urticaria unresponsive to standard therapy

Emergency preparedness:

  • Carry an epinephrine auto-injector if prescribed
  • Have an action plan for sudden or severe swelling
  • Seek immediate medical attention if airway obstruction occurs

With prompt treatment, avoidance of triggers, and emergency preparedness, most individuals with urticaria or angioedema can manage symptoms effectively and live normal, active lives.

References

  • Mayo Foundation for Medical Education and Research. (2024, April 3). Hives (Urticaria) and Angioedema.Mayo Clinic. https://www.mayoclinic.org
  • U.S. National Library of Medicine. (2024, March 5). Urticaria. MedlinePlus. https://medlineplus.gov
  • American Academy of Allergy, Asthma & Immunology. (2023). Urticaria and Angioedema. https://aaaai.org
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Affordable – with or without insurance

With Insurance

Without Insurance

*Price Effective 12/1/2025
$169
Initial Visit
$109
Follow Up

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Heading 6

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Unordered list

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