Membranous nephropathy (MN) is a kidney disorder characterized by thickening of the glomerular basement membrane due to immune complex deposition. This process causes damage to the glomeruli, resulting in proteinuria(excess protein in the urine), edema, and, in some cases, progressive kidney dysfunction.

MN is one of the most common causes of nephrotic syndrome in adults. It can occur primarily (idiopathic) or secondarily due to infections, autoimmune disorders, medications, or malignancies. Early diagnosis is essential to preserve kidney function and prevent complications.

Is it common?

MN is relatively common among adults with nephrotic syndrome, accounting for approximately 20–30% of adult cases. It is more frequently diagnosed in individuals aged 30–60 years and is slightly more common in men than women.

Can it be cured?

There is no guaranteed cure for MN. Some patients experience spontaneous remission, especially those with mild proteinuria, while others require immunosuppressive therapy to control protein loss and prevent progression to chronic kidney disease. Close monitoring of kidney function and proteinuria is essential to guide treatment.