Esophageal Diseases

About

Esophageal Diseases

What are Esophageal Diseases?

Esophageal diseases are conditions that affect the esophagus—the muscular tube that carries food and liquids from your mouth to your stomach. These disorders can interfere with swallowing, cause pain, or result in damage to the esophageal lining. Some of the most common esophageal conditions include gastroesophageal reflux disease (GERD), esophagitis, Barrett’s esophagus, esophageal strictures, and esophageal cancer.

The esophagus plays a key role in digestion. When it’s functioning normally, it uses rhythmic contractions (called peristalsis) to move food toward the stomach. When diseased or damaged, this process can be disrupted, leading to discomfort and other digestive issues.

Are Esophageal Diseases Common?

Yes, esophageal diseases—especially GERD—are quite common. GERD alone affects millions of adults in the U.S. Other conditions, like Barrett’s esophagus or esophageal cancer, are less common but can develop as complications of long-term reflux or inflammation.

Can Esophageal Diseases be cured?

Treatment depends on the type and severity of the condition. Many esophageal diseases can be effectively managed with lifestyle changes, medication, and sometimes minimally invasive procedures. In severe cases, surgery may be required. Early diagnosis and treatment can greatly improve outcomes and prevent complications.

Causes

What causes Esophageal Diseases?

The causes vary depending on the specific condition, but common factors include:

  • Chronic acid reflux (GERD) – when stomach acid frequently backs up into the esophagus.
  • Infection – viral, bacterial, or fungal infections can lead to esophagitis.
  • Autoimmune reactions – conditions like eosinophilic esophagitis occur when immune cells attack the esophagus.
  • Prolonged irritation – from smoking, alcohol, or certain medications.
  • Swallowing corrosive substances – such as accidentally ingesting cleaning chemicals.
  • Structural or motility disorders – like achalasia, where the lower esophageal sphincter fails to relax properly.

What are the risk factors?

You may have a higher risk of developing an esophageal disease if you:

  • Have chronic acid reflux or heartburn
  • Are overweight or obese
  • Smoke or use tobacco
  • Drink alcohol regularly
  • Eat a diet high in acidic or spicy foods
  • Have certain autoimmune or allergic conditions
  • Have a hiatal hernia
  • Are over age 50

With Insurance

Gastroenterology

Your copay
Depending on insurance

Without Insurance

*Price Effective 12/1/2025
$169
Initial Visit
$109
Follow Up
Gastroenterology

$149

Initial Visit

$99

Follow Up

Symptoms

What are the symptoms of Esophageal Diseases?

Symptoms depend on the condition but can include:

  • Difficulty swallowing (dysphagia)
  • Pain or burning in the chest (heartburn)
  • Regurgitation of food or sour liquid
  • Persistent cough or sore throat
  • Hoarseness or voice changes
  • Unexplained weight loss
  • Pain when swallowing
  • Vomiting or nausea

If you experience ongoing or severe symptoms, it’s important to see a doctor. Untreated esophageal issues can lead to more serious complications.

Diagnosis

How are Esophageal Diseases diagnosed?

Your doctor will review your symptoms and medical history and may perform one or more of the following tests:

  • Endoscopy (EGD) – A flexible tube with a camera is inserted down your throat to view the esophagus and stomach.
  • Biopsy – Small tissue samples may be taken during an endoscopy to check for inflammation, infection, or cancer.
  • Barium swallow (esophagram) – X-rays track the movement of a contrast liquid as you swallow to detect narrowing or structural problems.
  • Esophageal manometry – Measures the strength and coordination of muscle contractions in the esophagus.
  • pH monitoring – Detects how much acid is coming from the stomach into the esophagus over 24 hours.

Treatment

How are Esophageal Diseases treated?

Treatment depends on the specific diagnosis and severity of symptoms. Common options include:

  • Lifestyle changes:
    • Avoiding trigger foods (spicy, acidic, or fatty meals)
    • Eating smaller, more frequent meals
    • Avoiding lying down soon after eating
    • Losing weight if overweight
    • Quitting smoking and limiting alcohol
  • Medications:
    • Proton pump inhibitors (PPIs) or H2 blockers to reduce stomach acid
    • Antacids for occasional relief
    • Corticosteroids or other anti-inflammatory drugs for immune-related esophagitis
    • Antibiotics or antifungals for infections
  • Procedures or surgery:
    • Esophageal dilation for strictures (narrowing)
    • Fundoplication surgery for severe GERD
    • Endoscopic ablation or resection for Barrett’s esophagus or early-stage cancer

With the right treatment and lifestyle adjustments, most esophageal diseases can be effectively managed to improve comfort and quality of life.

References

Mayo Foundation for Medical Education and Research. (2024, March 22). Esophageal Conditions. Mayo Clinic. https://www.mayoclinic.org

U.S. National Library of Medicine. (2024, February 14). Esophageal Disorders. MedlinePlus. https://medlineplus.gov/esophagealdisorders.html

American College of Gastroenterology. (2023). GERD and Esophageal Diseases. https://gi.org

Medically reviewed by:

Dr. Javeed Siddiqui, MD, MPH

Dr. Siddiqui is the Chief Medical Officer at TeleMed2U responsible for clinical and technical program development as well as maintaining a thriving telemedicine practice in infectious diseases which includes specialized care of Hepatitis and HIV.

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Affordable – with or without insurance

With Insurance

Gastroenterology

Your copay
Depending on insurance

Without Insurance

*Price Effective 12/1/2025
$169
Initial Visit
$109
Follow Up
Gastroenterology

$149

Initial Visit

$99

Follow Up