Nonalcoholic Fatty Liver Disease

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What is Nonalcoholic fatty liver disease ?(NAFLD)?

Nonalcoholic Fatty Liver Disease (NAFLD) is a condition where excess fat builds up in the liver of individuals who drink little to no alcohol. It represents a spectrum of liver disorders that range from simple fat accumulation (steatosis) to inflammation and liver damage. NAFLD is one of the most common liver conditions worldwide and is closely linked with obesity, insulin resistance, type 2 diabetes, and high cholesterol.

While simple steatosis is generally benign, in some individuals, the disease can progress to a more severe form called Nonalcoholic Steatohepatitis (NASH), which may lead to fibrosis, cirrhosis, or even liver cancer.

Is Nonalcoholic fatty liver disease common?

Yes. NAFLD affects approximately 25–30% of adults globally, with higher prevalence in people who are overweight, have metabolic syndrome, or have type 2 diabetes. It is increasingly being recognized in children and adolescents due to rising obesity rates.

Can Nonalcoholic fatty liver disease be cured?

There is currently no specific medication to cure NAFLD, but the condition can often be reversed or stabilized through lifestyle changes such as weight loss, healthy diet, and regular physical activity. Early diagnosis and management are key to preventing progression to more severe liver disease.

Causes

What causes Nonalcoholic fatty liver disease?

NAFLD develops when the liver stores more fat than it can process. This imbalance is often linked to metabolic and lifestyle factors, including:

  • Obesity – excess body weight, especially around the abdomen
  • Insulin resistance – common in prediabetes or type 2 diabetes
  • High cholesterol or triglycerides
  • Poor diet – high in processed foods, sugars, and saturated fats
  • Sedentary lifestyle
  • Genetic predisposition – family history of fatty liver or metabolic disorders
  • Medications – such as corticosteroids, certain cancer drugs, or some antiretrovirals

With Insurance

Hepatology

Your copay
Depending on insurance

Without Insurance

*Price Effective 12/1/2025
$169
Initial Visit
$109
Follow Up

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Symptoms

What are the symptoms of Nonalcoholic fatty liver disease?

NAFLD is often called a “silent” disease because most people do not experience noticeable symptoms, especially in the early stages. When symptoms occur, they may include:

  • Fatigue or general malaise
  • Discomfort or pain in the upper right abdomen
  • Unexplained weight gain or difficulty losing weight
  • Enlarged liver (hepatomegaly) detected during examination
  • In advanced stages: jaundice, swelling in the legs or abdomen, or confusion (signs of liver failure)

Diagnosis

How is Nonalcoholic fatty liver disease  diagnosed?

Diagnosis is based on a combination of clinical evaluation, imaging, and laboratory testing:

  • Medical history and physical exam – assessing risk factors such as obesity, diabetes, and alcohol intake
  • Blood tests – elevated liver enzymes (ALT, AST) may indicate liver inflammation
  • Imaging studies – ultrasound, CT scan, or MRI can detect fat accumulation
  • FibroScan (transient elastography) – measures liver stiffness to assess fibrosis
  • Liver biopsy – definitive test to distinguish between simple steatosis and NASH

Treatment

How is Nonalcoholic fatty liver disease ( treated?

Treatment focuses on reversing fat accumulation and preventing liver damage through lifestyle and medical management:

Lifestyle changes:

Aim for weight loss of 7–10%, which can significantly reduce liver fat and inflammation

Follow a Mediterranean-style diet rich in vegetables, whole grains, and lean proteins

Engage in regular physical activity (at least 150 minutes per week of moderate exercise)

Avoid sugary drinks, alcohol, and processed foods

Medical management:

  • Control of diabetes, high blood pressure, and cholesterol
  • Vitamin E or pioglitazone may be used in select cases under specialist supervision.
  • Regular monitoring with blood tests and imaging

Procedures:

  • Bariatric surgery may be considered for severe obesity with liver disease
  • Liver transplantation in end-stage cases

With early diagnosis and consistent management, NAFLD can often be reversed and long-term liver complications prevented.

References

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Affordable – with or without insurance

With Insurance

Hepatology

Your copay
Depending on insurance

Without Insurance

*Price Effective 12/1/2025
$169
Initial Visit
$109
Follow Up

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Heading 4

Heading 5
Heading 6

Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur.

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  3. Item 3

Unordered list

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