Anaphylaxis

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What is Anaphylaxis?

Anaphylaxis is a severe, rapid-onset allergic reaction that affects the whole body and can be life-threatening if not treated immediately. It occurs when the immune system overreacts to a trigger, such as food, medication, insect stings, or other allergens, causing widespread release of histamine and other chemicals.

Anaphylaxis can impact multiple organ systems, including the skin, respiratory tract, gastrointestinal tract, and cardiovascular system. Symptoms can develop within minutes to hours after exposure and may progress rapidly. Prompt recognition and treatment are essential to prevent serious complications or death.

Is Anaphylaxis common?

Anaphylaxis is less common than mild allergic reactions but can occur in anyone at any age. Certain triggers, like peanuts, tree nuts, shellfish, insect stings, or medications, increase the likelihood of a severe reaction. People with a history of allergies or asthma are at higher risk.

Can Anaphylaxis be cured?

Anaphylaxis cannot be “cured,” but it can be prevented and effectively treated. Avoiding known triggers is critical, and immediate use of epinephrine during an attack can save lives. Long-term management includes education, emergency action plans, and sometimes allergy immunotherapy for specific triggers.

Causes

What causes Anaphylaxis?

Anaphylaxis is triggered by a rapid immune system response to allergens, including:

  • Foods – peanuts, tree nuts, shellfish, milk, eggs, soy, wheat
  • Medications – antibiotics, NSAIDs, or other prescription drugs
  • Insect stings – bees, wasps, hornets, or fire ants
  • Latex – medical gloves or other latex-containing products
  • Exercise-induced anaphylaxis – sometimes linked to food intake
  • Unknown triggers – in some cases, no clear cause is identified

What are the risk factors?

You may be more likely to experience anaphylaxis if you:

  • Have a known severe allergy to food, medication, or insect stings
  • Have asthma or other respiratory conditions
  • Have a history of previous anaphylactic reactions
  • Are exposed to multiple triggers simultaneously
  • Delay treatment during a prior allergic reaction

With Insurance

Without Insurance

*Price Effective 12/1/2025
$169
Initial Visit
$109
Follow Up

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Symptoms

What are the symptoms of Anaphylaxis?

Symptoms typically occur quickly and can affect multiple systems:

  • Skin: hives, redness, swelling, or itching
  • Respiratory: difficulty breathing, wheezing, throat tightness, hoarseness
  • Cardiovascular: rapid or weak pulse, low blood pressure, dizziness, fainting
  • Gastrointestinal: nausea, vomiting, abdominal pain, diarrhea
  • General: anxiety, confusion, feeling of impending doom

Anaphylaxis can progress rapidly to shock or respiratory failure. If any signs of a severe allergic reaction occur, use epinephrine immediately if available and call 911 or your local emergency number right away.

Diagnosis

How is Anaphylaxis diagnosed?

Anaphylaxis is primarily diagnosed based on clinical signs and symptoms, often in the context of recent allergen exposure. Tests may include:

  • Patient history – prior allergic reactions, triggers, timing, and severity
  • Physical examination – skin, respiratory, and cardiovascular assessment
  • Blood tests – measurement of tryptase levels shortly after the reaction may confirm anaphylaxis
  • Allergy testing – conducted later to identify specific triggers once the patient has stabilized

Rapid recognition is crucial, as anaphylaxis can worsen within minutes.

Treatment

How is Anaphylaxis treated?

Immediate treatment is essential and may include:

Emergency treatment:

  • Epinephrine (adrenaline) injection – first-line treatment for severe reactions
  • Call emergency services immediately, even after using epinephrine
  • Positioning – lying down with legs elevated to support blood flow
  • Supplemental oxygen or intravenous fluids – to support breathing and circulation

Additional medications:

  • Antihistamines – to relieve itching or hives
  • Corticosteroids – to reduce inflammation (may help prevent recurrence)
  • Bronchodilators – for wheezing or airway constriction

Long-term management:

  • Avoidance of known allergens
  • Emergency action plan – including carrying epinephrine auto-injectors
  • Medical identification – wearing a medical alert bracelet or necklace
  • Follow-up with an allergist – for testing, immunotherapy, and education

Prompt recognition and immediate treatment can save lives and prevent severe complications from anaphylaxis. Call 911 (or your local emergency number) immediately after using epinephrine, as symptoms can return or worsen.

References

  • Mayo Foundation for Medical Education and Research. (2024, March 22). Anaphylaxis. Mayo Clinic. https://www.mayoclinic.org
  • U.S. National Library of Medicine. (2024, February 15). Anaphylaxis. MedlinePlus. https://medlineplus.gov
  • American Academy of Allergy, Asthma & Immunology. (2023). Anaphylaxis: Diagnosis and Treatment.https://aaaai.org
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Affordable – with or without insurance

With Insurance

Without Insurance

*Price Effective 12/1/2025
$169
Initial Visit
$109
Follow Up

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Unordered list

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