Pancreatic Diseases

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Pancreatic Diseases

What are Pancreatic Diseases?

Pancreatic diseases are conditions that affect the pancreas — a vital organ located behind the stomach that produces enzymes for digestion and hormones like insulin that regulate blood sugar. When the pancreas becomes inflamed, damaged, or develops abnormal growths, it can disrupt both digestive and metabolic functions.

Common pancreatic diseases include pancreatitis (acute or chronic inflammation of the pancreas), pancreatic cysts, pancreatic cancer, and pancreatic insufficiency (when the pancreas doesn’t produce enough digestive enzymes). Because the pancreas plays a central role in both digestion and blood sugar control, disorders affecting it can have widespread effects on overall health.

Are Pancreatic Diseases common?

Some pancreatic diseases, such as acute pancreatitis, are relatively common and often caused by gallstones or alcohol use. Others, like pancreatic cancer or chronic pancreatitis, are less common but more serious. Early diagnosis and treatment are essential to prevent complications such as diabetes, malnutrition, or life-threatening infections.

Can Pancreatic Diseases be cured?

Many pancreatic diseases can be effectively managed with prompt treatment. Most mild cases of Acute pancreatitis often resolve with medical care and lifestyle changes, while chronic pancreatitis and pancreatic insufficiency require ongoing management. Pancreatic cancer treatment depends on the stage and may include surgery, chemotherapy, or targeted therapies. Early detection offers the best outcomes.

Causes

What causes Pancreatic Diseases?

The causes depend on the specific condition but may include:

  • Gallstones – blocking the pancreatic duct and triggering inflammation.
  • Chronic alcohol use – a leading cause of chronic pancreatitis.
  • High triglyceride levels – which can inflame the pancreas.
  • Infections – viral or bacterial.
  • Certain medications – that irritate or damage pancreatic tissue.
  • Genetic factors – hereditary pancreatitis or cystic fibrosis.
  • Pancreatic duct obstruction – from scarring, tumors, or trauma.
  • Autoimmune reactions – where the immune system attacks the pancreas.

What are the risk factors?

You may be more likely to develop a pancreatic disease if you:

  • Consume alcohol frequently
  • Smoke or use tobacco products
  • Have gallstones or high triglycerides
  • Have a family history of pancreatic disease or cancer
  • Have diabetes or obesity
  • Have cystic fibrosis or certain genetic syndromes
  • Are over age 50

With Insurance

Gastroenterology

Your copay
Depending on insurance

Without Insurance

*Price Effective 12/1/2025
$169
Initial Visit
$109
Follow Up
Gastroenterology

$149

Initial Visit

$99

Follow Up

Symptoms

What are the symptoms of Pancreatic Diseases?

Symptoms vary depending on the condition but often include:

  • Upper abdominal pain that may radiate to the back
  • Nausea and vomiting
  • Fever (with inflammation or infection)
  • Jaundice (yellowing of the skin or eyes)
  • Unintentional weight loss
  • Fatigue or weakness
  • Loss of appetite
  • Oily or foul-smelling stools (steatorrhea)
  • Elevated blood sugar or new-onset diabetes

Pancreatic pain is often severe and persistent, especially in pancreatitis. If you experience these symptoms, seek medical attention immediately, as some pancreatic diseases can be life-threatening.

Diagnosis

How are Pancreatic Diseases diagnosed?

Your healthcare provider will start with a physical exam and review of your symptoms, followed by one or more of the following tests:

  • Blood tests – to check pancreatic enzymes (amylase and lipase) and liver function.
  • Ultrasound or CT scan – to visualize inflammation, cysts, or masses.
  • MRI or MRCP (Magnetic Resonance Cholangiopancreatography) – detailed imaging of the pancreas and bile ducts.
  • Endoscopic Ultrasound (EUS) – to obtain high-resolution images and tissue samples.
  • ERCP (Endoscopic Retrograde Cholangiopancreatography) – to diagnose and sometimes treat duct blockages.
  • Stool tests – to check for fat malabsorption, indicating pancreatic insufficiency.

Treatment

How are Pancreatic Diseases treated?

Treatment depends on the specific diagnosis and severity but may include:

  • Lifestyle and dietary changes:
    • Avoiding alcohol and tobacco
    • Following a low-fat, nutrient-rich diet
    • Eating small, frequent meals
    • Staying hydrated
  • Medications:
    • Pain relievers to manage discomfort
    • Pancreatic enzyme supplements for digestion prescribed by the Provider
    • Insulin or other medications for blood sugar control
    • Antibiotics if infection is present
    • Medications to lower triglyceride levels
  • Procedures and surgery:
    • Endoscopic treatments (ERCP) to remove blockages or place stents
    • Surgery to remove damaged tissue, cysts, or tumors
    • Chemotherapy or radiation therapy for pancreatic cancer
    • Drainage procedures for pancreatic pseudocysts

Prompt treatment and lifestyle adjustments can help manage symptoms, prevent complications, and improve quality of life for those with pancreatic diseases.

References

Mayo Foundation for Medical Education and Research. (2024, April 15). Pancreatitis and Pancreatic Diseases. Mayo Clinic. https://www.mayoclinic.org

U.S. National Library of Medicine. (2024, February 25). Pancreatic Disorders. MedlinePlus. https://medlineplus.gov/pancreaticdisorders.html

American College of Gastroenterology. (2023). Pancreatic Diseases and Treatments. https://gi.org

Medically reviewed by:

Dr. Javeed Siddiqui, MD, MPH

Dr. Siddiqui is the Chief Medical Officer at TeleMed2U responsible for clinical and technical program development as well as maintaining a thriving telemedicine practice in infectious diseases which includes specialized care of Hepatitis and HIV.

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Affordable – with or without insurance

With Insurance

Gastroenterology

Your copay
Depending on insurance

Without Insurance

*Price Effective 12/1/2025
$169
Initial Visit
$109
Follow Up
Gastroenterology

$149

Initial Visit

$99

Follow Up