Chronic Kidney Disease

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What is Chronic Kidney Disease (CKD)?

Chronic Kidney Disease (CKD) is a long-term condition in which the kidneys gradually lose their ability to filter waste, balance fluids, and regulate minerals. This decline happens over months to years and can eventually lead to kidney failure if not managed appropriately. CKD is typically irreversible but can be slowed significantly with early diagnosis and proper treatment. 

The kidneys normally filter the blood continuously, removing toxins, producing urine, controlling blood pressure, and regulating red blood cell production. When damaged, these functions deteriorate, causing waste products to accumulate and leading to complications such as hypertension, anemia, bone disease, nerve problems, and cardiovascular disease.

Is Chronic Kidney Disease common?

Yes. CKD is common — affecting roughly 1 in 7 adults in many countries (about 35 million adults in the U.S.). Risk increases with age and is higher in people with diabetes, high blood pressure, heart disease, obesity, or a family history of kidney disease. Many people are unaware they have CKD because early stages are often asymptomatic. 

Can Chronic Kidney Disease be cured?

CKD cannot be cured in most cases, but progression can often be slowed or stabilized—especially when detected early. Treatment focuses on controlling underlying causes (like diabetes and hypertension), lifestyle changes, and close monitoring. In advanced stages, dialysis or kidney transplantation may be required. 

Causes

What causes Chronic Kidney Disease?

CKD results from long-term damage to kidney tissue from a variety of causes:

  • Diabetes — high blood sugar damages kidney blood vessels (diabetic nephropathy) and is the leading cause worldwide.
  • Hypertension — chronically high blood pressure injures renal arteries and filtering units. 
  • Glomerular diseases — such as glomerulonephritis or IgA nephropathy. 
  • Genetic disorders — e.g., polycystic kidney disease. National Kidney Foundation
  • Chronic infections or reflux — repeated pyelonephritis or reflux nephropathy with scarring. 
  • Long-term obstruction — kidney stones, enlarged prostate causing back pressure. 
  • Medications/toxins — prolonged use of certain NSAIDs, some antibiotics, or herbal supplements. 

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Nephrology

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*Price Effective 12/1/2025
$169
Initial Visit
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Follow Up

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Symptoms

What are the symptoms of Chronic Kidney Disease?

CKD often progresses silently. Symptoms may not appear until significant function is lost. Common signs, when present, include:

  • Fatigue and weakness
  • Swelling in legs, ankles, or around the eyes
  • Changes in urination (foamy urine, frequency changes, nighttime urination)
  • Loss of appetite, nausea, or weight loss
  • Persistent itching
  • Muscle cramps, especially at night
  • High blood pressure
  • Trouble concentrating or shortness of breath (from fluid overload or anemia)

Advanced CKD can lead to severe electrolyte disturbances, fluid overload, and uremia.

Diagnosis

How is Chronic Kidney Disease diagnosed?

Diagnosis combines lab testing, imaging, and clinical evaluation:

  • Blood testseGFR (estimated glomerular filtration rate) is used to assess kidney function; an eGFR <60 mL/min/1.73 m² for ≥3 months indicates CKD. Creatinine and BUN help assess filtration and waste retention. 
  • Urine tests — urine albumin-to-creatinine ratio (uACR) detects proteinuria/albuminuria, an early marker of kidney damage. 
  • Imaging — renal ultrasound assesses size, scarring, cysts, or obstructive causes.
  • Kidney biopsy — sometimes necessary when glomerular disease is suspected or etiology is unclear. 

CKD is staged (1–5) based on eGFR and albuminuria category to guide management and referral. 

Treatment

How is Chronic Kidney Disease treated?

Treatment aims to slow progression, manage complications, and preserve quality of life. 

Lifestyle & preventive measures
  • Control blood pressure and blood sugar.
  • Reduce salt intake and follow a kidney-friendly diet (protein, potassium, phosphorus adjusted as needed).
  • Exercise regularly, maintain healthy weight, avoid smoking, and limit NSAID use. 
Medical management
  • Blood pressure control (ACE inhibitors or ARBs are commonly recommended to reduce proteinuria and slow CKD progression when appropriate). 
  • Diabetes management — tight glycemic control and use of evidence-based agents as appropriate. 
  • Anemia treatment — iron therapy and erythropoiesis-stimulating agents when indicated.
  • Mineral and bone disorder management — phosphate binders, vitamin D analogues as needed.
Monitoring & referral
  • Regular eGFR and urine albumin monitoring, plus management of cardiovascular risk. Refer to nephrology when eGFR declines or albuminuria is significant (local guidance often suggests referral for eGFR <30 mL/min/1.73 m² or uACR >300 mg/g). 
Advanced therapies
  • Dialysis (hemodialysis or peritoneal) for kidney failure (stage 5) or uremic complications.
  • Kidney transplantation — definitive therapy for eligible patients.
  • Conservative/palliative care may be considered for those who opt out of dialysis. 
When to seek urgent care

Seek immediate medical attention for:

  • Chest pain
  • Severe shortness of breath
  • Confusion or altered mental status
  • Rapidly declining urine output

With early detection, targeted treatment, and regular follow-up, many people with CKD can slow progression and reduce complications.

References

  1. National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) — Chronic Kidney Disease (CKD). NIDDK
  2. Kidney Disease: Improving Global Outcomes (KDIGO) — CKD evaluation and management & 2021 BP guideline (clinical practice guidelines). KDIGO+1
  3. National Kidney Foundation (NKF) — CKD overview, albuminuria information, and clinical action algorithms. National Kidney Foundation+1
  4. Mayo Clinic — Chronic kidney disease: symptoms, causes, diagnosis, and treatment. Mayo Clinic+1
  5. NIDDK Kidney Disease Statistics (U.S. prevalence).

Medically reviewed by:

Dr. Javeed Siddiqui, MD, MPH

Dr. Siddiqui is the Chief Medical Officer at TeleMed2U responsible for clinical and technical program development as well as maintaining a thriving telemedicine practice in infectious diseases which includes specialized care of Hepatitis and HIV.

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With Insurance

Nephrology

Your copay
Depending on insurance

Without Insurance

*Price Effective 12/1/2025
$169
Initial Visit
$109
Follow Up

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