What is Primary sclerosing cholangitis (PSC)?

Primary Sclerosing Cholangitis (PSC) is a chronic, progressive liver disease in which inflammation and scarring (fibrosis) occur within the bile ducts—the tubes that carry bile from the liver to the gallbladder and small intestine. Over time, this scarring causes the ducts to narrow and harden, leading to bile buildup, liver damage, and eventually cirrhosis or liver failure.

PSC is believed to be immune-mediated, though its exact cause remains unclear. It’s often associated with inflammatory bowel disease (IBD), particularly ulcerative colitis, and primarily affects men between ages 30 and 50.

Is Primary sclerosing cholangitis common?

PSC is rare, affecting about 1 in 10,000 people. Despite its rarity, it’s a significant cause of chronic liver disease and one of the leading reasons for liver transplantation in adults.

Can Primary sclerosing cholangitis be cured?

There is no known cure for PSC, but medical management and monitoring can help slow disease progression, relieve symptoms, and prevent complications. In advanced cases, liver transplantation offers an excellent long-term outcome and can be life-saving.