Biliary Diseases

About

Biliary Diseases

What are Biliary Diseases?

Biliary diseases refer to conditions that affect the bile ducts, gallbladder, and the bile system — the network that helps transport bile from the liver to the small intestine. Bile is a digestive fluid that plays an important role in breaking down fats and removing waste from the body. When any part of this system becomes blocked, infected, or inflamed, it can lead to serious digestive and metabolic issues.

Common biliary diseases include gallstones (cholelithiasis), cholecystitis (inflammation of the gallbladder), biliary obstruction, primary sclerosing cholangitis, and bile duct cancer (cholangiocarcinoma).

Are Biliary Diseases common?

Yes. Gallstones are among the most common biliary conditions, affecting millions of people worldwide. While many people with gallstones have no symptoms, others may develop severe pain or may also result from benign strictures or post-surgical scarring. Other biliary diseases are less common but can cause significant complications if untreated.

Can Biliary Diseases be cured?

Many biliary conditions can be treated successfully, especially when detected early. Gallstones, for example, can often be managed with lifestyle changes, medications, or minimally invasive procedures like laparoscopic surgery. Chronic conditions, such as primary sclerosing cholangitis, may not be curable but can be controlled with proper medical care and monitoring to prevent complications.

Causes

What causes Biliary Diseases?

The causes vary depending on the specific condition but may include:

  • Gallstones – hardened deposits that form in the gallbladder and can block bile flow.
  • Infection or inflammation – bacterial infections or autoimmune reactions that affect the bile ducts.
  • Bile duct obstruction – from stones, scarring, or tumors.
  • Genetic or autoimmune disorders – such as primary biliary cholangitis or sclerosing cholangitis.
  • Post-surgical complications – scarring or narrowing of the bile ducts after gallbladder surgery.

What are the risk factors?

You may be more likely to develop a biliary disease if you:

  • Are overweight or obese
  • Eat a high-fat, low-fiber diet
  • Have rapid weight loss or fasting habits
  • Have a family history of gallstones or biliary disease
  • Particularly in women over 40
  • Have certain liver diseases or autoimmune conditions
  • Take medications that increase cholesterol in bile

With Insurance

Gastroenterology

Your copay
Depending on insurance

Without Insurance

*Price Effective 12/1/2025
$169
Initial Visit
$109
Follow Up
Gastroenterology

$149

Initial Visit

$99

Follow Up

Symptoms

What are the symptoms of Biliary Diseases?

Symptoms may vary depending on the underlying cause, but common signs include:

  • Pain in the upper right abdomen or mid-abdomen (often after eating fatty foods)
  • Nausea or vomiting
  • Indigestion or bloating
  • Jaundice (yellowing of the skin or eyes)
  • Dark urine or pale-colored stools
  • Fever or chills (signs of infection)
  • Itchy skin (from bile buildup in the bloodstream)

If a bile duct becomes completely blocked or infected, it can cause a medical emergency requiring immediate treatment.

Diagnosis

How are Biliary Diseases diagnosed?

Your healthcare provider will begin with a review of your symptoms and medical history, followed by one or more of these diagnostic tests:

  • Ultrasound – the first-line test to detect gallstones or bile duct obstruction.
  • CT or MRI scan – provides detailed images of the liver, gallbladder, and bile ducts.
  • HIDA scan (hepatobiliary iminodiacetic acid scan) – evaluates gallbladder function and bile flow.
  • Endoscopic Retrograde Cholangiopancreatography (ERCP) – combines endoscopy and X-rays to view bile ducts and remove stones or blockages.
  • Blood tests – check liver enzymes, bilirubin, and infection markers.

Treatment

How are Biliary Diseases treated?

Treatment depends on the cause, severity, and overall health of the patient. Options include:

  • Lifestyle and dietary changes:
    • Eating a balanced, low-fat diet
    • Staying hydrated
    • Avoiding rapid weight loss or crash diets
    • Maintaining a healthy body weight
  • Medications:
    • Antibiotics for infections
    • Ursodeoxycholic acid to dissolve small gallstones or improve bile flow
    • Pain relievers and anti-nausea medications for symptom relief
  • Procedures and surgeries:
    • Cholecystectomy: Surgical removal of the gallbladder, often done laparoscopically
    • ERCP: To remove bile duct stones or place stents for drainage
    • Percutaneous drainage or surgery: For severe infections or blockages
    • Liver transplant: In rare cases of advanced disease, such as primary sclerosing cholangitis

With prompt and proper treatment, most biliary diseases can be managed effectively, allowing patients to return to normal activities and avoid long-term complications.

References

Mayo Foundation for Medical Education and Research. (2024, April 12). Biliary Conditions and Gallbladder Disease.Mayo Clinic. https://www.mayoclinic.org

U.S. National Library of Medicine. (2024, February 21). Bile Duct and Gallbladder Disorders. MedlinePlus. https://medlineplus.gov/bileductandgallbladderdiseases.html

American College of Gastroenterology. (2023). Biliary Tract Diseases. https://gi.org

Medically reviewed by:

Dr. Javeed Siddiqui, MD, MPH

Dr. Siddiqui is the Chief Medical Officer at TeleMed2U responsible for clinical and technical program development as well as maintaining a thriving telemedicine practice in infectious diseases which includes specialized care of Hepatitis and HIV.

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Affordable – with or without insurance

With Insurance

Gastroenterology

Your copay
Depending on insurance

Without Insurance

*Price Effective 12/1/2025
$169
Initial Visit
$109
Follow Up
Gastroenterology

$149

Initial Visit

$99

Follow Up