Eosinophilic Esophagitis

About

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What is Eosinophilic Esophagitis?

Eosinophilic esophagitis (EoE) is a chronic immune-mediated condition in which the esophagus — the tube that carries food from the mouth to the stomach — becomes inflamed due to an accumulation of eosinophils, a type of white blood cell. This inflammation can lead to difficulty swallowing, food impaction, and chronic discomfort.

EoE is often triggered by allergens, including certain foods or environmental allergens, and is considered part of the spectrum of allergic and immune-mediated disorders. It can affect both children and adults and may coexist with other allergic conditions such as asthma, eczema, or allergic rhinitis.

Is Eosinophilic Esophagitis common?

EoE is increasingly recognized worldwide, though it remains relatively rare. It affects males more often than females and can appear at any age. Early diagnosis is important to prevent complications such as esophageal narrowing or strictures.

Can Eosinophilic Esophagitis be cured?

EoE cannot currently be cured, but symptoms can be effectively managed. Treatment focuses on reducing inflammation, relieving symptoms, and preventing long-term complications. With proper care, patients can maintain a normal quality of life.

Causes

What causes Eosinophilic Esophagitis?

EoE is often triggered by allergens, especially certain foods and sometimes environmental allergens, and is considered part of the spectrum of allergic and immune-mediated disorders.. Common causes include:

  • Food allergens – milk, eggs, wheat, soy, peanuts, tree nuts, seafood
  • Environmental allergens – pollen, dust mites, pet dander
  • Genetic predisposition – family history of EoE or other atopic conditions
  • Immune system dysfunction – overactivation of eosinophils leads to inflammation
  • Other allergic conditions – asthma, eczema, or allergic rhinitis

What are the risk factors?

You may be more likely to develop EoE if you:

  • Have a personal or family history of allergies or atopic conditions
  • Are male
  • Have other allergic disorders such as asthma or eczema
  • Have a history of gastrointestinal reflux disease (GERD) or chronic esophageal irritation

With Insurance

Without Insurance

*Price Effective 12/1/2025
$169
Initial Visit
$109
Follow Up

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Symptoms

What are the symptoms of Eosinophilic Esophagitis?

Symptoms can vary by age and severity but often include:

  • Difficulty swallowing (dysphagia)
  • Food getting stuck in the esophagus (food impaction)
  • Chest pain or discomfort, unrelated to heart conditions
  • Persistent heartburn or acid reflux symptoms
  • Nausea or vomiting
  • Poor growth or feeding difficulties in children
  • Unintentional weight loss in severe cases

Symptoms are often chronic and may worsen with certain foods or allergens.

Diagnosis

How is Eosinophilic Esophagitis diagnosed?

Diagnosis involves a combination of clinical evaluation and specialized testing:

  • Medical history – assessing symptoms, triggers, and allergic background
  • Endoscopy – visual examination of the esophagus to detect inflammation, rings, or narrowing
  • Biopsy – tissue samples taken during endoscopy to measure eosinophil counts and confirm inflammation
  • Allergy testing – skin prick or blood tests to identify potential triggers
  • Imaging studies – occasionally used to assess esophageal structure in severe cases

Accurate diagnosis is important to differentiate EoE from GERD or other esophageal disorders.

Treatment

How is Eosinophilic Esophagitis treated?

Treatment focuses on reducing inflammation, managing symptoms, and avoiding triggers:

Lifestyle and dietary changes:

  • Elimination diets – removing specific allergenic foods from the diet
  • Elemental diets – using amino acid-based formulas for severe cases
  • Avoiding environmental allergens – pollen, dust, and pet dander when possible
  • Medications:
  • Topical corticosteroids – swallowed inhaler medications or specially prepared solutions or lozenges that are swallowed to coat the esophagus and reduce inflammation
  • Proton pump inhibitors (PPIs) – to manage reflux and reduce inflammation
  • Biologic therapies – for severe or refractory cases under specialist supervision

Procedures:

  • Esophageal dilation – for narrowing or strictures to improve swallowing
  • Follow-up endoscopy – to monitor inflammation and healing

With timely diagnosis and consistent management, most patients with EoE can achieve symptom relief, prevent complications, and maintain normal eating habits.

References

  • Mayo Foundation for Medical Education and Research. (2024, March 28). Eosinophilic Esophagitis. Mayo Clinic. https://www.mayoclinic.org
  • U.S. National Library of Medicine. (2024, February 22). Eosinophilic Esophagitis. MedlinePlus. https://medlineplus.gov
  • American College of Gastroenterology. (2023). Eosinophilic Esophagitis Guidelines. https://gi.org
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Affordable – with or without insurance

With Insurance

Without Insurance

*Price Effective 12/1/2025
$169
Initial Visit
$109
Follow Up

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Heading 5
Heading 6

Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur.

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Unordered list

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Bold text

Emphasis

Superscript

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